时间：2016年7月11日（周一）16:00 -17:00
地点：仓山校区光电学院四层学术报告厅
主讲：加拿大 University Health Network，Juan Chen 研究员
主办：光电与信息工程学院、福建省光子技术重点实验室、医学光电科学与技术教育部重点实验室
专家简介：Dr. Juan Chen received her Ph.D in applied chemistry from the Research Institute of Petrochemical Processing, China. She received postdoctoral training in the department of radiology at University of Pennsylvania with Dr. Gang Zheng, where she involved the design and development of photodynamic molecular beacons and lipid-based nanoparticles. Dr. Chen is currently the research project manager in Dr. Zheng’s lab at University Health Network in Toronto. Her research interests include the development and evaluation of smart probes for molecular imaging/phototherapy and nano-based platforms for drug/probe delivery.
报告摘要：Porphyrins are aromatic, organic, light–absorbing molecules that occur abundantly in nature, especially in the form of molecular self-assemblies. In 2011, we discovered “porphysome”, the self-assembled porphyrin-lipid nanoparticles with intrinsic multimodal properties. The high density porphyrin packing in bilayer enables the “super” absorption and conversion of light energy to heat with extremely high efficiency, making them ideal for photothermal therapy and photoacoustic imaging. Upon nanostructure dissociation, fluorescence and photodynamic activity of porphyrin monomers are restored, allowing low background fluorescence imaging and activatable photodynamic therapy. In addition, metal ions can be directly incorporated into theporphyrin building blocks of the preformed porphysomes, unlocking their potential for PET and MRI applications. By changing the way of porphyrin-lipid assembly, we developed HDL-like porphyrin nanoparticles (20 nm),porphyrin microbubble (~2μm), giant porphyrin vesicle (~100 μm) and hybrid porphyrin-gold nanoparticles. By mimicking light harvest system in photosynthetic bacteria, we introduced high-ordered porphyrin aggregates into supramolecular assemblies, resulting unprecedented photonic properties. By expending the 4-coordination state of porphyrin to 5-coordination state of texaphyrin-lipid building blocks with stable chelation of 18 metals ions, we developed texaphyrin nanoassembly, unleashing the metal chelating power of texaphyrins for a wide array of nanomedicine application. Together, the simple yet intrinsic multimodel nature of porphyrin self-assembly represents a new frontier in cancer imaging and therapy.